Some of the prioritized BW-MVPs were situated in genes strongly involved in glucose and/or lipid metabolism or have been implicated in T2D or obesity risk (for example, APPL2, IGF2BP2, PHKG2 and PPARGC1B), which is in line with the observation that low birth weight is associated with increased metabolic disease risk. This evidence concerns the gene APPL2 and obesity due to melanocortin 4 receptor deficiency.