Some of the prioritized BW-MVPs were situated in genes strongly involved in glucose and/or lipid metabolism or have been implicated in T2D or obesity risk (for example, APPL2, IGF2BP2, PHKG2 and PPARGC1B), which is in line with the observation that low birth weight is associated with increased metabolic disease risk. The gene discussed is IGF2BP2; the disease is obesity due to melanocortin 4 receptor deficiency.