As shown in Table 1, a total of 275 patients with severe sepsis were included, 80 with genotype CC (or male hemizygous C), 55 with genotype CT and 140 with genotype TT (or male hemizygous T) of the 372 T/C genetic polymorphism of TIMP-1 (rs4898). The gene discussed is TIMP1; the disease is Sepsis.