Occupational asthma involves IgE-mediated asthma after a latency period, irritant asthma with or without a latency period, including reactive airways dysfunction syndrome (RADS), resulting from high exposure, and asthma due to specific occupational agents with unknown pathomechanisms that may also show a latency period [2,3] (Figure 1). This evidence concerns the gene IGHE and occupational asthma.