While in WI or CS group they appear inhibited or reduced, we showed a trend towards increased for TGFβ and a significant rise of its first downstream mediator pSmad3 in WI + CS, indicate a maintain production of collagen and a progression of renal fibrosis accentuated by MMP-2 decrease expression supporting a less extracellular matrix degradation. This evidence concerns the gene MMP2 and renal fibrosis.