GRM5 and fragile X syndrome: In addition, Western blot analyses consistently revealed a stronger mGluR5 band corresponding to a molecular mass of 150 kDa in FXS patients or carriers (Figure 1C), with the average mGluR5: total protein ratio higher and significant (+32%; t = 2.07, df = 28, P = 0.048) for FXS patients or carriers (mean = 1.32, standard deviation = 0.16) than for control samples (mean = 1.0, standard deviation = 0.05; Figure 1D).