In our study, miR-93 was underexpressed in the serum of women who developed HER-2-overexpressing breast tumors; interestingly, miR-93 expression was recently shown to induce a more differentiated cell phenotype in breast cancer cell lines, and expression of miR-93 in mouse mammary fat pads blocked tumor development and metastases [44]. This evidence concerns the gene ERBB2 and breast neoplasm.