The effects of ROS on activation of JNK and IKK were arranged to reproduce the data from DLD1 cells (human colon carcinoma) in Essers et al. [44]; with the attribution of the inhibition at high oxidative stress to IKK- mediated degradation of FOXO (measured in 293T and MCF-7 cells by Hu et al. [47]). The gene discussed is MAPK8; the disease is colon carcinoma.