In contrast to the healthy donor cohort, where phospho-AKT expression levels clustered around 1 (1.0 for Ser472 and 0.97 for Thr308) on a normalized relative expression level scale (standard deviation 0.3 each), acute leukemia specimens were frequently found to have augmented phosphorylation patterns of AKT. The gene discussed is AKT1; the disease is acute leukemia.