Using Jurkat cells, a PTEN-deficient acute lymphoblastic leukemia cell line rendering AKT signaling pathways autoactivated [31], we now provide evidence that NVP-BGT226 is capable of inhibiting oncogene-driven PI3K/AKT/MTOR signal transduction pathways in acute leukemia. The gene discussed is PTEN; the disease is acute lymphoblastic leukemia.