DFFA and infection: In fact, in recent studies [28,29], S. epidermidis is the most common cause of clinical infections because of strains that are able to produce a polysaccharide slime depending on the presence of ica, such as icaD. This finding suggests the possibility that co-expression of mecA and icaD is associated with enhanced clinical isolates that produce an extracellular matrix called slime and may make them more resistant to antibiotics.