RASSF1 and esophageal squamous cell carcinoma: Of particular interest, we also demonstrated the similar hypermethylation of RASSF1A in GCA (65%, 60/92), the promoter hypermethylation of RASSF1A significantly increased 7.5-fold higher the risk to GCA (OR=7.5, 95% CI=2.78–20.23), which is very similar as in ESCC.