Interestingly, the similar results were observed in GCA, the promoter hypermethylation of RASSF1A gene significantly increased almost 7.5-fold higher the risk to GCA development (65% in GCA vs. 20% in adjacent normal mucosa, OR=7.50, 95% CI=2.78–20.23) (Table 2 and Figure 2). Here, RASSF1 is linked to temporal arteritis.