By 5 months post-transplant, two out of eight mice in the KO to KO transplant group had succumbed to tumor pathology, including one case of CD4+ T-cell lymphoma in the thymus and one case of kidney tumor, with no tumors observed in any of the other groups (Figure 3—figure supplement 1A,B). Here, CD4 is linked to T-cell non-Hodgkin lymphoma.