The target of rapamycin (TOR) complexes (TORC1 and TORC2) are known to function in sensing various nutrient signals (Ma and Blenis, 2009; Laplante and Sabatini, 2012; Zoncu et al., 2012), and their roles are connected to growth, metabolism, stress responses, and cancers (Hansen et al., 2008; He and Klionsky, 2009; Howell and Manning, 2011). The gene discussed is CRTC1; the disease is cancer.