CRTC1 and cancer: Both ceramide and TORC1 have been individually implicated for roles in stress response, apoptosis, cancers, and other cellular processes by studies in C. elegans and mammals (Hannun and Obeid, 2008; Hansen et al., 2008; He and Klionsky, 2009; Howell and Manning, 2011; Laplante and Sabatini, 2012; Menuz et al., 2009; Zoncu et al., 2011).