Other possible genetic candidates include the ESR1 gene which is associated with both adult height and age at onset of RA [2], [46], and several genes implicated in both the extracellular matrix pathway and adult height, including MMP24, ECM2, EFEMP1, ADAMTS13 and ACAN [2], [36], [47]. This evidence concerns the gene EFEMP1 and rheumatoid arthritis.