To verify the importance of B2285 in regulating abnormal immune responses of SLE and reveal the potential mechanism of anti-B2285 Abs in treating the disease, we tested and found that anti-B2285 Abs obviously inhibited the generation of anti-dsDNA Abs in SLE mice, along with the decreased Th1 and Th17 cells. The gene discussed is DDX41; the disease is systemic lupus erythematosus.