Despite the different sources of macrophages, our studies using either lung resections or bronchoscopies have not shown corticosteroid insensitivity in COPD macrophages compared to controls [10], [11], and in all these experiments we have observed that CXCL8 was less corticosteroid sensitive than other cytokines. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.