HPSE and cancer: These genes have a strong correlation with angiogenesis (Hif1a, FLT1) [4], [5] and lead to alterations of the extracellular matrix and remodeling of subepithelial and subendothelial basal membranes (heparanase, HPSE) [6], [7] and therefore seem to be directly involved in the aggressiveness of cancers.