BRCA1 and breast cancer: Strikingly, the DEABM was able to reproduce the notable increase in breast cancer susceptibility seen in BRCA patients by 55 years of age (reference range of cumulative cancer incidence ranging from 17–58%) [46]–[50], with simulation results demonstrating cumulative cancer incidences increasing to 31.6% BRCA1 (range from 30.6–33.6%) from the 3.6% incidence seen the sporadic group (Figure 7A).