In addition, recent accumulated evidences revealed a number of risk factors of gastric cancer (T allele at rs2294008, blood type A, decreased gastric acid, intake of proton pump inhibitor/H2 blocker, and CagA in H. pylori[31]) or peptic ulcer (C allele at rs2294008, blood type O, NSAID intake, dupA in H. pylori) [32]. This evidence concerns the gene S100A8 and peptic ulcer disease.