Research studies conducted over the last decade on melanoma molecular pathogenesis improved the elucidation of its key signaling pathways, such as those mediated by Ras/Raf/MEK/ERK (alias MAPK), PI3K/Akt/mTOR, Wnt/b-catenin/APC, MITF and glutamate cascade [2]. Here, MAP2K7 is linked to melanoma.