This is because: 1) c-Myc overexpression promotes prostate cancer development [18]; 2) c-Myc is upregulated in androgen ligand-dependent prostate cancer and further upregulated in CRPC [19], [20]; and 3) prior reports have demonstrated that c-Myc, like AR, contributes to ligand-independent prostate cancer cell growth [21]. This evidence concerns the gene MYC and Familial prostate cancer.