c-Myc is commonly upregulated in prostate cancer, and c-Myc overexpression transforms normal prostatic epithelial cells in genetically engineered mouse models of prostate cancer and confers ligand-independent prostate cancer cell survival, but the dependency of c-Myc expression on the AR was unclear [18], [20], [21], [33]. This evidence concerns the gene MYC and Familial prostate cancer.