Differential expression analysis of DCIS and IDC in young women revealed significant down regulation of PI3K, DUSP6, CD22, RB, BCR, MS4A1 (also known as CD20), and MAP3K5 as well as alterations in PI3K/Akt, NFkB, Jnk, and ERK pathways. The gene discussed is DUSP6; the disease is ductal breast carcinoma in situ.