BRCA1 and breast cancer: As it has been shown that centrosome maturation from late S to M phase is essential in the completion of mitosis [51] and that Aurora-A has a role in inhibiting BRCA1-mediated centrosome nucleation in the late G2-M phase [52], the K309T VUS identified in breast cancer patients is a candidate mutation that may promote aberrant chromosome segregation resulting in multi-nucleation and multi-centrosomes often associated with breast cancers [53], [54].