Results showed that EE fails to ameliorate HH mediated memory impairment in presence of Trk antagonist i.e. K252a (Fig. 3) as evident from increased path-length (Fig. 3A), latency (Fig. 3B), decreased time spent in target quadrant (Fig. 3C) and number of platform crossing (Fig. 3D). The gene discussed is NTRK1; the disease is memory impairment.