Consistent with echocardiographic results obtained 3 days post-MI, cardiac dysfunction was significantly attenuated in TNFR1−/− mice compared to WT ($$P<0.01) 7 days post-MI, evidenced by decreased LVEDP (Figure 4A) and increased ±dP/dtmax (Figure 4B, C). This evidence concerns the gene TNFRSF1A and myocardial infarction.