We also observed the upregulation of glioma specific proteins [11] in the differentiating GIC03A and GIC03U, such as vimentin, VEGF, EGFR, MAPKs, KRAS, Musashi, FABP7, S100B, Cathepsin B, BAX, BAD, BID, CDK4, CDK6, as well as CD44, GFAP in proteomics or mRNA levels during 2 to 7 days of the serum stimulation of GICs (Table S2). The gene discussed is CTSB; the disease is glioma.