WFS1 and type 2 diabetes mellitus: Although there is some evidence that WFS1 is involved in Ca2+ homeostasis and influences the stability of the ER stress sensor ATF6 (Fonseca et al, 2010; Osman, 2003; Takei et al, 2006), the exact function of WFS1, its regulation, and the molecular mechanisms linking its function to Wolfram Syndrome and type 2 diabetes are far from resolved.