Although there is some evidence that WFS1 is involved in Ca2+ homeostasis and influences the stability of the ER stress sensor ATF6 (Fonseca et al, 2010; Osman, 2003; Takei et al, 2006), the exact function of WFS1, its regulation, and the molecular mechanisms linking its function to Wolfram Syndrome and type 2 diabetes are far from resolved. The gene discussed is WFS1; the disease is Wolfram syndrome.