This type of cell death may have wide significance in immune responses because it is mediated by NLRP3, a protein that senses not only pathogens but also danger-associated signals, and presumably contributes to neutrophil infiltration in urticarial rashes in CAPS or other diseases such as gout in which NLRP3 is proposed to contribute to the pathogenesis. Here, NLRP3 is linked to gout.