This report led us to compare pyronecrosis and pyroptosis, the latter being caspase-1-dependent programmed necrosis in response to intracellular bacteria such as Salmonella. 21, 22 Pyroptosis requires caspase-1 activity and is inhibited by caspase-1 inhibitor or pan-caspase inhibitor Z-VAD-fmk.23, 24, 25 Our data, however, demonstrated that a caspase-1 inhibitor did not inhibit pyronecrosis, cell death caused by CAPS-associated mutant NLRP3 expression. This evidence concerns the gene CASP1 and cryopyrin-associated periodic syndrome.