We previously reported that cell death induced by LPS treatment of monocytes isolated from CAPS patients was blocked by cathepsin B inhibitor CA074-Me,7 and that the cell death induced by transient expression of CAPS-associated mutant NLRP3 was blocked by CA074-Me and caspase inhibitors.9 The cell death caused by CAPS-associated NLRP3 mutants in the Tet-on system (Figure 3a) was attenuated by both CA074-Me and pan-caspase inhibitor Z-VAD-fmk (Figure 3a). This evidence concerns the gene CTSB and cryopyrin-associated periodic syndrome.