We have recently reported that Cyr61, a membrane-bound integrin interactor protein, is a resistance factor to the proapoptotic effect of ZOL in androgen-independent PCa cells.33 Interestingly, cross-talk between Cyr61 activation and p38-MAPK has been reported elsewhere.34, 35 A potential role of p38-MAPK activation and/or of its downstream target HSP27 in the resistance to N-BP treatment has also been previously proposed in breast cancer17 and osteosarcoma12, 18 preclinical models. The gene discussed is CCN1; the disease is posterior cortical atrophy.