ZEB1 and neoplasm: Furthermore, we demonstrated that DU145R80, compared with parental DU145 cells, undergo EMT, a key process required during embryonic development that is associated with a tumour initiating/stem-like phenotype and that occurs in, and may contribute to, PCa progression and metastasis.21 In particular, we found that DU145R80 reduced the expression of the homotypic cellular adhesion molecule E-cadherin, the main molecular alteration involved in EMT21 by upregulating the expression of its suppressor ZEB1.