BCL2 and prostate intraepithelial neoplasia: Conversely, our findings further support the view of an aggressive phenotype in DU145R80 cells because Bcl-2 expression was significantly upregulated in PCa with an aggressive phenotype, as indicated by the correlation with a high Gleason score, advanced stage and high proliferation index.27 However, c-Myc appears to be activated at the earliest phases in prostatic intraepithelial neoplasia, contributing to disease initiation and progression, and c-Myc is a key precursor lesion for invasive prostatic adenocarcinoma.28, 29