GPT and anemia (phenotype): Major non hematological toxicities (grade 3–4) concerned mainly hepatic enzymes, particularly GGT that increased in 5.5 % of cases Minor toxicities (grade I–II) were anemia (42.1 %), thrombocytopenia (15.1 %), leukopenia (9.2 %), AST/ALT increase (approximately 40 %), worsening of renal function (2.8 %), and gastrointestinal toxicity (6.2 %).