In glioma cells, it has been shown that HGF stimulates the transcription of EGFR ligands such as transforming growth factor α (TGF α) and heparin-binding EGF-like growth factor (HB-EGF), whose inhibitions result in the failure of EGFR activation involving Y845 phosphorylation [91]. The gene discussed is HBEGF; the disease is glioma.