EGFR and breast cancer: In the cell proliferation and malignancy of MCF7 and SUM149 breast cancer cells, Src-dependent (i.e., dasatinib-sensitive) Y845 phosphorylation (i.e., Y845F mutation-sensitive) signaling was shown to require the activity of p38 MAPK, but not the activity of the EGFR/kinase ERK/MAPK, as well as Akt [127].