EGFR and malignant colon neoplasm: Other cellular functions involving Y845 phosphorylation include wound-induced activation of the Src/EGFR pathway in corneal epithelial cells [170], intestinal cell proliferation and tumorigenesis that can be inactivated by the interaction of farnesoid X receptor with Src, leading to the inactivation of Src and the decrease in Y845 phosphorylation [171], and colon cancer proliferation that is stimulated by Src-mediated aryl hydrocarbon receptor and EGFR interactions, leading to Y845 phosphorylation and ERK/MAPK activation [172].