EGFR and urinary bladder carcinoma: In the case of bladder carcinoma cells, disruption of the membrane microdomains by methyl-β-cyclodextrin results in the interference with Src-dependent signal transduction and the promotion of apoptosis under serum-deprived culture conditions [89,90], although its relationship to the phosphorylation state of EGFR (i.e., Y845) is unknown.