EGFR and squamous cell carcinoma: Phosphotyrosine-based proteome analysis has been employed in squamous carcinoma cells overexpressing EGFR (HN5) to elucidate the interactive networks involved in EGFR Y845 phosphorylation and activation, leading to the identification of its cross-talk relationship with not only well-characterized proteins, but also poorly described proteins such as desmoplakin3, a progesterone target of adhesion-related proteins [109].