EGFR and non-small cell lung carcinoma: Choi et al. [187] and Yang et al. [188] have shown that, in L834R and/or L837Q mutants of EGFR, which are pathologically found in NSCLC and 32D cells, Y845 phosphorylation takes place in an erlotinib-sensitive, but EGF- and Src-independent manner.