In HER2-overexpressing breast cancer cells, SK-BR-3, endothelin-induced transactivation of EGFR via phosphorylation of Y845 has been demonstrated, and dual targeting of the endothelin and EGFR systems, using atrasentan and trastuzumab, respectively, was shown to be effective in reducing cell proliferation and invasion [110]. The gene discussed is EGFR; the disease is breast carcinoma.