EGFR and squamous cell carcinoma: On the other hand, Wang et al. [154] have shown that, in squamous carcinoma cells, SCC12, the depletion of ganglioside GM3, which has been reported to be inhibitory to the integrin-dependent activation of EGFR, induces the phosphorylation of EGFR on Y845, Y1068, and Y1148, but not on Y1086 and Y1173.