EGFR and non-small cell lung carcinoma: In an attempt to elucidate the mechanism of nuclear translocation/localization of EGFR in cetuximab-resistant NSCLC cells (NCI-H226), Iida et al. [179] have shown that Y1101, but not Y845, in EGFR is a critical tyrosine residue that is phosphorylated by Yes and Lyn.