EGFR and breast carcinoma: More recently, Miyake and Parsons [68] have shown that choline kinase α, an enzyme that converts choline to phosphocholine in the phosphatidylcholine synthesis and whose overexpression correlates with poor prognosis, high grade and increased aggressiveness in some types of human cancer, interacts directly with EGFR, is tyrosine-phosphorylated in an Src-dependent manner, and contributes to breast cancer cell proliferation.