Buerger et al. [193] have reported the screening and identification of a short peptide aptamer that interacts with the kinase domain of EGFR and interferes with certain steps of EGFR signaling, including Y845 phosphorylation, Shc and STAT3 activations, and the growth of Herc cells (NIH3T3 overexpressing EGFR), SKBR breast cancer cells, and A431 cells, but not ERK/MAPK activation. The gene discussed is EGFR; the disease is breast cancer.