Ishiwata, et al., first found that the USP14 expression was upregulated in leukemic cells in 2001 [15], Shinji et al., found that the USP14 expression in colorectal cancer is associated with liver and lymph node metastases in 2006, and Chuensumran, et al., found that USP14 expression is associated with intrahepatic cholangiocarcinoma cell differentiation in 2011 [16,17]. This evidence concerns the gene USP14 and colorectal cancer.