GRN and systemic lupus erythematosus: In this study, we tested serum levels and mRNA levels of PGRN, IL-6, proteinase3 (PR3), TNFR, TNF-α in the peripheral blood mononuclear cells (PBMCs) of SLE patient and normal controls and dsDNA antibody to investigate the possible role of PGRN in SLE patients.