Among the 66 HTx recipients or patients referred for HTx evaluation (Heart Failure Clinic) and the 44 consecutive DCM patients referred for familial evaluation to the Unit for Screening Studies in Inherited Cardiovascular Disease, we identified nine LMNA mutations including p.Arg541Cys, p.Arg541Gly and p.Tyr481* previously described by our team and three novel mutations: p.Gly400Argfs*11, p.Ser431* and p.Val256Gly. Here, LMNA is linked to familial dilated cardiomyopathy.