Indeed, detailed uPAR immunohistochemistry studies on tumour tissue have revealed that an increasing uPAR expression is present at the very front of the invasive tumour, and uPAR is therefore considered a potential local marker for invasive cancers (Pyke et al., 1994; Dublin et al., 2000; Jacobsen & Ploug, 2008; Van & Van, 2009; Alpízar-Alpízar et al., 2012). Here, PLAUR is linked to neoplasm.