EP300 and chondrosarcoma: In this context the role of p300,an enzyme possessing a histone acetyltransferase(HAT) activity, was observed in several studies.Using the chondrosarcoma cell line SW1353,Tsuda et al. have shown that Sox9 associates withCREB-binding protein (CBP)/p300 via its carboxyltermini activation domain and functions asan activator for cartilage tissue-specific gene expressionduring chondrocyte differentiation (77).Later, Furumatsu et al. have investigated the molecularmechanism of synergy between Sox9 andp300 in chromatin mediated transcription on chromatinizedtemplates in vitro.