We and others have shown that experience of transgenic mice expressing familial Alzheimer's disease (FAD)-linked mutant amyloid precursor protein (APP) and/or presenilin-1 (PS1) in environmental enrichment (EE) rescues impaired neurogenesis, enhances hippocampal long-term potentiation (LTP) and upregulates gene expression of molecular targets associated with learning and memory, synaptic plasticity and neuronal survival [2]–[4]. The gene discussed is PSEN1; the disease is familial Alzheimer disease.