The reason for the lack of correlation between sCD4 level and disease activities of SLE patients may be due to that the SLEDAI score gathered in this study is skewed to lower side and the heterogeneity of clinical manifestations in SLE patients also contributes to the difficulty in evaluating the relationship between soluble CD4 level and disease activities of SLE patients. This evidence concerns the gene SCD5 and systemic lupus erythematosus.