Reciprocally, abolition of AIF/EndoG-dependent apoptosis by AIF- or EndoG-siRNA enhanced Atg5 and Atg7 expression induced by FK-16 (Fig. 5D), indicating that inhibition of AIF/EndoG-dependent apoptosis magnified the autophagic signal in FK-16-treated colon cancer cells. Here, ENDOG is linked to colonic neoplasm.