Since the Bcl-2 family has been reported to regulate both caspase-independent apoptosis and autophagy in other biological contexts [30], [32], we next questioned if FK-16-induced colon cancer cell death was mediated through Bcl-2 and Bax, both of which were downstream of p53 (Fig. 3B). This evidence concerns the gene BCL2 and malignant colon neoplasm.