The genetic variations of SORCS1, the most recent member of the Vps10 family proteins [18], was also found to be associated with AD [20], [22], [29], [30] in Caribbean Hispanics, Caucasian Hispanics and et al. In our current study, rs10884402 and rs950809 in intron 1 of SORCS1 were found to be associated with LOAD in Chinese Han population. This evidence concerns the gene SORCS1 and Alzheimer disease.