In intact colon, the gene expression patterns in 12 week old Il10−/− mice compared to age-matched C57BL/6J mice, or 6 week old Il10−/− mice, were consistent with other studies of colon gene expression in the Il10−/− model [14], [34], [40] and in other mouse models of IBD [7]. Here, IL10 is linked to inflammatory bowel disease.