In this study, chow-fed C57BL/6 mice were injected with OXT via the third ventricle consecutively for 7 days, and from Day 4 to Day 7, these mice received daily i.p. injections of STZ to induce moderate beta cell damages., Results showed that as a result of STZ-impaired insulin secretion, vehicle-treated mice displayed hyperglycemia and glucose intolerance; however, OXT treatment led to significant improvements in glucose tolerance (Fig. 7A) and blood insulin levels (Fig. 7B). This evidence concerns the gene INS and Glucose intolerance.