The six subtypes were named according their main respective biological characteristic as follows: C1, “CINImmuneDown”; C2, “dMMR”; C3, “KRASm” (for “KRAS-mutant”); C4 “CSC” (for “cancer stem cell”); C5, “CINWntUp”; and C6, “CINnormL”. This evidence concerns the gene KRAS and cancer.