Resveratrol, a stilbene primarily found in red grapes, apples, and peanuts, can be useful to counteract obesity, metabolic disorders, CVD, and cancer, through multiple actions: it increases mitochondrial activity, counteracts lipid accumulation, decreases inflammation, improves insulin signaling and modulates redox balance. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.