SERPINE1 and coronary artery disorder: In patients with stable coronary artery disease, daily consumption of a resveratrol-containing grape supplement (8 mg resveratrol) for one year provided a cardiovascular benefit, by increasing serum adiponectin, preventing plasminogen activator inhibitor-1 (PAI-1) increase and inhibiting atherothrombotic signals, in peripheral blood mononuclear cells [213].