Oxidative stress activates stress signaling kinases, among which c-jun N terminal kinase 1 (JNK1) plays a key role in the aetiology of insulin resistance: by phosphorylating IRS-1 at inhibitory sites, JNK1 prevents recruitment of this protein to the activated insulin receptor and disrupts downstream events of the insulin signaling pathway. The gene discussed is MAPK8; the disease is Insulin resistance.