In breast cancer cells, plitidepsin induces several early response genes such as c-JUN, JUNB, JUND, c-FOS, FOSB and FRA1, as well as RELA/p65, the major component of the nuclear transcription factor kappa B (NFkB), while also decreasing the cellular content of the c-MYC protein [6]. The gene discussed is RELA; the disease is breast carcinoma.