PTPA and Alzheimer disease: Lastly, use of OA in cortical neurons has recently led to the identification of a novel signaling role of PP2A through the prolyl-isomerase Pin1 [48] which was proposed as a therapeutic target to reduce aberrant phosphorylation of neurofilament proteins in neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease, and amyotrophic lateral sclerosis.