Although RORA has never before been associated with ASD, our recent studies have demonstrated: reduced expression of RORA in lymphoblastoid cell lines (LCL) derived from individuals with autism[13]; increased methylation leading to reduced expression of RORA in the LCL from cases vs. sibling controls[11]; and decreased expression of RORA protein in the prefrontal cortex and the cerebellum of individuals with autism[11]. Here, RORA is linked to autism.