Decreased mRNA and protein expression of NRF2 and OGG1 in E2-treated mammary tissues and in E2-induced mammary tumors after 240 days of E2 treatment and corresponding increased mRNA and protein expression of these genes after Vit C or BHA treatment suggest NRF2-mediated regulation of OGG1 (Figures 2, 3A and 3B). This evidence concerns the gene NFE2L2 and breast cancer.