TKT and cancer: Targeting of Src (SmTK3) [34] and Syk (SmTK4) [31] kinases with their respective TK inhibitors herbimycin and piceatannol was shown to have a marked effect on reproduction processes of S. mansoni and the anti-cancer drug Imatinib (STI-571, Gleevec) that targets Abl kinases led to important alterations of parasite gastrodermis and caused the death of parasites in vitro[32], [35].