Similarly, gene variants in TAS2Rs are related to disease – a polymorphism in TAS2R38 contributes to an increased susceptibility to respiratory infection [34] and a mutation in TAS2R50 has been associated with cardiovascular disease in several population-based prospective studies [35], [36], but the mechanisms by which the variants of these TAS2 genes influence the pathophysiology of disease are mostly unknown. The gene discussed is TAS2R38; the disease is cardiovascular disorder.