As p300 HAT is usually involved in global histone H3K27 acetylation and GCN5 HAT functions to regulate global histone H3K9 acetylation [22], [25], human PDAC tumor samples were stained for histone H3K9 and H3K27 acetylation by IHC and trichrome stained to assess for fibrosis. The gene discussed is EP300; the disease is neoplasm.